Tianchang Capsule prevents ovariectomy induced osteoporosis in rats

This article performed a model of osteoporosis rats using the method ovariectomy and observed efficacy Tianchang Capsule on treatment rats. Comparing effect with positive drug to explore mechanism in postmenopausal osteoporosis. Female SD were randomly assigned 6 groups (10 each group): control (sham-treated), OVX (by ovariectomy), OVX+AL ovariectomy, received alendronate sodium), OVX+LTC low dosage Capsule), OVX+MTC middle OVX+HTC high Capsule). After operation, or Tian Chang capsule given for 12 weeks. Bone metabolism was measured by bone mineral density (BMD). With 12-week treatment, BMD reduced group, formation resorption parameters increased however, pathological sections indicated destruction trabecular structure meanwhile (P < 0.05 P 0.01). In sodium treatments groups, comparing control, both significantly level improved tissue damage, also inhibit excessive actively used as good natural drugs induced rats, increasing density, resorption.